The Clinical Importance Of The Synaptophysin Antibody

by | Feb 17, 2017 | Science and Technology

The Synaptophysin antibody is considered to be a major synaptic vesicle protein and is found in humans. It is encoded by the SYP gene. This gene is located on the shorter arm of the X chromosome and is 12,406 bases in length. It usually likes on the minus strand and is predicted to have a molecular weight of 33.845 kDa. Likewise, it is said to have 313 amino acids, as well.

Molecular Biology

The Synaptophysin antibody has four transmembrane domains, and it is present in almost all the neurons of the brain and spinal cord, especially those that use synaptic transmission. It is also present in neuroendocrine cells and acts as a marker for tumors of the neuroendocrine cells. Because of its nature, it has been used as an immunostaining option for a variety of synapses.

The function of this protein isn’t known, though scientists do know that it interacts with the protein synaptobrevin, which is an essential synaptic vesicle. However, if it is inactivated in animals experimentally, they can still function and develop normally. Research has shown that if it is eliminated in mice, it can lead to behavioral changes, including reduced spatial learning, impaired object recognition, and more exploratory behavior.

The Importance

The inability to produce or have this antibody has been implicated in mental retardation, which is why scientists are trying to learn more and do more research. It can be used in Immunohistochemistry applications and can be demonstrated in a variety of neuroendocrine and neural tissues, including the pancreatic islets and adrenal medulla cells. Scientists can identify tumors, such as retinoblastoma, neuroblastoma, small-cell carcinoma, medullary thyroid carcinoma, and medulloblastoma, as well as others.

The Synaptophysin antibody is an essential part of research. Visit Spring Bioscience now to purchase yours or learn more.

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